Similarly, aortas from the mice of Ang II-induced hypertension (Fig. 5C) and of HFD-induced dyslipidemia (Fig. 5D) shared the same pathway, manifesting as an impaired acetylcholine-induced vessel relaxation (Fig. 5C and 5D) which were associated the PA700/S10B-mediated 26S proteasome activation (Fig. 3B, 3C, 4B, and 4C). Here, AGT is linked to metabolic syndrome.