We did not observe a burst release of insulin when the particles were triggered with glucose concentrations analogous to hypoglycemia (5 mmoles/L, ∼90 mg/dL) and normoglycemia (7 mmoles/L, ∼126 mg/dL), suggesting that the AVTs are suitable for maintaining normal blood glucose levels (Figure 8B). The gene discussed is INS; the disease is Hypoglycemia.