In line with observations that PR physically and/or functionally interacts with other TFs, we revealed that, among others, the FOX family member motifs are specifically enriched at PR targets in breast cancer cells, whereas HSF, TEF-1, and C/EBP motifs are overrepresented in leiomyoma cells, suggesting that through interaction with those TFs, PR may produce cell-specific effects. Here, PGR is linked to leiomyoma.