Nevertheless, the requirement of multiple PR-binding sites per RU486-regulated gene alone cannot account for the extreme discordance between the number of RU486-regulated genes (375) and PR-binding sites (31,457) in T47D cells, and the number of RU486-regulated genes (61) and PR-binding sites (7,034) in leiomyoma cells. The gene discussed is PGR; the disease is leiomyoma.