IGHE and asthma: Studies from the Inner-City Asthma Consortium showed that allergen-specific IgE levels were correlated with allergen exposure among sensitized participants (P < 0.0001 for cockroach), and specific IgE levels for cockroach are also correlated with a range of inflammatory, physiologic, and clinical markers, suggesting that the allergen-specific IgE level could be a surrogate measure of the combination of sensitization plus degree of exposure, and ultimately asthma severity [35].