We previously found that 21 SNPs in 14 allergy candidate genes on chromosomes 4, 5, 6, 9, 10, 11, 12, 16, and 20 are associated with elevated levels of CBIgE [78], a finding similar to findings of the studies on genetic association of serum IgE and asthma [79, 80]. Here, IGHE is linked to allergic disease.