Similarly, IgSF members such as L1CAM (CD171), NCAM (CD56), PECAM-1 (CD31), ALCAM (CD166), and ICAM-1 (CD54) have been associated with metastatic progression in a range of cancers including melanoma, glioma, breast, ovarian, endometrial, prostate, and colon cancer [11–15]. The gene discussed is L1CAM; the disease is melanoma.