Cell-surface glycosylation is upregulated in many different cancers [91], and a number of glycoproteins have been identified as ligands for galectin-3, including integrin β1, lysosome-associated membrane proteins 1 and 2 [92], and the IgSF members carcinoembryonic antigen (CEA) and L1CAM [51, 52]. The gene discussed is L1CAM; the disease is cancer.