BACE1 activity increases, and correlations with amyloid pathology were most consistently found not only in AD-vulnerable brain regions such as the temporal cortex, the hippocampal region, as well as the prefrontal cortex [32] but also in some less vulnerable structures in the diencephalon and brain stem including the thalamus and the pons [33, 34]. Here, BACE1 is linked to Alzheimer disease.