Mutations in the GPIb-IX-V complex (Bernard-Soulier syndrome), integrin αIIbβ3 (Glanzmann thrombasthenia), or the MYH9 gene that encodes the heavy chain of nonmuscle myosin IIA (May-Hegglin anomaly, Fechtner, Epstein, and Sebastian syndromes) can lead to serious bleeding disorders due to impaired adhesion, aggregation, or clot stability [155,156]. The gene discussed is MYH9; the disease is macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.