Hence, methylation levels of ZPBP2 exon 1 influence ZPBP2 RNA levels and explain the apparent contradiction between high in vitro activity and FAIRE enrichment of the ZPBP2 promoter region and lower expression of ZPBP2 in LCLs that carry the asthma-associated haplotype HapA. This evidence concerns the gene ZPBP2 and asthma.