The ZPBP2 promoter was highly methylated in cell lines homozygous for the asthma-associated HapA haplotype (n = 5) and in heterozygous cell lines (n = 6), but had lower methylation levels in cell lines that were homozygous for the non-asthma associated HapB haplotype (n = 5). The gene discussed is ZPBP2; the disease is asthma.