This was the platform on which the discoveries of Raynaud (discovery of Raynaud's disease or phenomenon), Langerhans (discovery of islet cells in the pancreas, which secrete insulin, and also the dendritic cells in the skin known as Langerhans cells), and Duchesne (discovery of a type of muscular dystrophy) were built [18]. The gene discussed is INS; the disease is muscular dystrophy.