CXCL1 and multiple sclerosis: Furthermore, the importance of examining whether blocking CXCL1 would be safe in the long term and efficient in all types of EAE and multiple sclerosis is underscored by the observations that CXCL1 influences the biology of myelinating cells [45-48] and that both CXCL1 expression and neutrophil infiltration are higher during Th17 cell-mediated EAE compared to Th1 cell-mediated EAE [12,13].