The circulating levels of endostatin in healthy individuals was reported to be between 10 to 50 ng/mL which is equivalent to 0.5–2.5 nM however, elevated levels of endostatin were reported in several cancer types that include osteosarcoma, NSCLC, hepatocellular carcinoma, ovarian cancer, bladder cancer, head and neck squamous cell carcinoma, renal cell carcinoma, soft tissue sarcoma, acute myeloid leukemia and colorectal cancer. This evidence concerns the gene COL18A1 and hepatocellular carcinoma.