By knockdown of p53 protein expression with siRNA, we found that LMP1 promotes p53-mediated survivin upregulation by increasing survivin promoter activity and p53-survivin DNA binding activity, suggesting the complexity of the regulation of p53 on survivin mediated by viral oncoprotein LMP1 in NPC. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.