In summary, our study verified that p53 as a transcriptional factor, could upregulate survivin expression in both the transcriptional level and protein level mediated by LMP1, and further stabilized the nuclear localization of survivin, ultimately resulting in G1/S cell cycle progression but not the induction of apoptosis in NPC (Fig. 6). This evidence concerns the gene BIRC5 and nasopharyngeal carcinoma.