A number of groups have shown that inhibition or deletion of inducible NOS results in suppression of tumor growth and metastasis (Ohtsu et al., 2010; Thomsen et al., 1997); we also found that treatment with 1400W prior to intravenous injection of 1 × 106 LLC cells causes a significant reduction in metastatic success in vivo (Figure 5C). The gene discussed is NOS2; the disease is neoplasm.