Hypoxic response via HIF activation also includes expression of factors such as vascular endothelial growth factor (VEGF), and inducible nitric oxide synthase (iNOS) that are known to facilitate both angiogenesis and tumor cell access to the circulatory system (Ambs et al., 1998; Claffey et al., 1996; Shweiki et al., 1992; Ziche and Morbidelli, 2009). Here, NOS2 is linked to neoplasm.