IGHE and allergic disease: A limitation of this study is the fact that BAT and FEIA were compared to SPT, which is not a definitive diagnostic test, as 29-46% asymptomatic persons are SPTpos for at least one of 10 common allergens,[25] and some patients with provocation tests or clinical history strongly suggesting allergic disease due to a specific allergen and elevated serum levels of IgE to that allergen are SPTneg for that allergen [26,27].