These loci include CBARA1, ARHGAP15, and RNF216. CBARA1 regulates calcium uptake by the mitochondria [17], ARHGAP15 may be involved in survival after acute lung injury [18], and RNF216 encodes an enzyme that inhibits NF-kappa B activation pathways [19], which are involved in HIF-α induction [20]. This evidence concerns the gene RNF216 and injury.