Applying a cut-off value represented by the median + 2SD from the control group, 43.9% of RA, 77.6% of OA, 84.6% of ReA, 20% of PsA, 6.7% of AS, 67.9% of SLE, 87.5% of SSc patients, and 5.2% of healthy controls tested positive for COMP-C3b. Here, COMP is linked to systemic sclerosis.