It has since been confirmed that leptin increases migration through the MAPK and PI3K pathways in prostate [37, 39, 40], liver [26], cartilage [32], and breast [23, 40, 64] cancers, as well as the JAK-STAT pathway in colon [35], prostate [39], liver [26], and breast [23] cancers. The gene discussed is LEP; the disease is cancer.