Patients who had mild asymptomatic hematologic abnormalities (anemia, leucopenia, and increased erythrocyte sedimentation rate), positive anti-SSA/Ro or/and anti-SSB/La, and negative serology for hepatitis C, EBV, cytomegalovirus, and human immunodeficiency virus were included in the probable preclinical pSS group. This evidence concerns the gene SSB and peeling skin syndrome.