FHIT and head and neck squamous cell carcinoma: Chromosomal aberrations identified with the help of cytogenetic methods including FISH, cCGH, or aCGH showed the gain of the entire long arm of chromosome 3 which amplifies the EGFR gene in SCCHN [53], 8q24 gain to amplify MYC and PTK2 in primary tumors, 11q13 amplifications to amplify cyclin D1 gene, loss of 3q14 causes deletion of fragile site FRA3B/FHIT, necessary to protect cells from accumulation of DNA damage [48].