CXCL8 and obesity due to melanocortin 4 receptor deficiency: We tested the regulation of the proinflammatory genes CD14, IL6, IL8, monocyte chemoattractant protein 1 (MCP1), CCl2, PAI1, and tumor necrosis factor-alpha (TNFα) and the anti-inflammatory genes CD163, interleukin 1 receptor antagonist (IL1ra), and IL10, all reported to code for secreted proteins that are up-regulated in obesity (Fain 2010).