Some publications have provided support for our hypothesis, Cimmino et al. [28] have demonstrated that miR-15a and miR-16 expression is inversely correlated with bcl-2 expression in Chronic lymphocytic leukemia and that both microRNAs negatively regulate bcl-2 at a post-transcriptional level. Here, BCL2 is linked to B-cell chronic lymphocytic leukemia.