This adds the TBC1D20/Rab1 axis to other identified factors of the secretory pathway that influence HIV replication cycle, such as Rab5, 6a, 7, 9 and 11a, [1,42-45]; and places TBC1D20 in the network of host regulators of the late stages of HIV infection. The gene discussed is RAB1A; the disease is HIV infectious disease.