These mice display a constitutive expression of NF-κB proteins in macrophages and monocytes, but no spontaneous myelopoetic phenotype thus allowing for studying the role of this transcription factor in myelin-oligodendrocyte-glycoprotein induced experimental autoimmune encephalomyelitis (MOG-EAE). This evidence concerns the gene NFKB1 and experimental autoimmune encephalomyelitis.