BMP2 and polycystic ovary syndrome: It was reported that Met can protect against neurotoxicity, in addition to its antidiabetic effect, and it has a number of important, diverse functions, including in polycystic ovarian syndrome, induction of osteoblasts via AMP-activated protein kinase (AMPK) signaling pathway along with subsequent enhancement of nitric oxide synthase (eNOS) and bone morphogenetic-2 protein (BMP-2) production [37,38].