Finally, we discovered a variety of orthologs of human genes implicated in specific disorders, including Leigh syndrome, Hyper-IgD syndrome, immunodeficiency associated with hyper IgM, Griscelli syndrome, STAR syndrome and Charcot-Marie-Tooth disease, retinitis pigmentosa and generalized epilepsy. This evidence concerns the gene CD40LG and hyperimmunoglobulinemia D with periodic fever.