Sensory5 Genes-bridging integrator 3-mal, T-cell differentiation protein(protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis [45])-NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18 kDa (NADH-coenzyme Q reductase)(Leigh syndrome [49])-caspase 9, apoptosis-related cysteine peptidase(colon cancer [42], inflammatory bowel disease [43])-snail homolog 1(Drosophila)(colon cancer [47]). The gene discussed is CASP9; the disease is malignant colon neoplasm.