Immune and Hematopoietic9 Genes-tumor protein D52-like 2(childhood leukemia [83])-fragile histidine triad gene(breast cancer [50], inflammatory bowel disease [84])-tetraspanin 33-beclin 1, autophagy related(Alzheimer's disease [51], colorectal cancer [56], glioblastoma multiforme [55])-uracil-DNA glycosylase(hyper-IgM syndrome [57])-solute carrier family 35, member C1(leukocyte adhesion deficiency II [85])-linker for activation of T cell-bridging integrator 3-interleukin 1 receptor antagonist(coronary artery disease [77], autoinflammatory disease [54]). The gene discussed is TPD52L2; the disease is early-onset autosomal dominant Alzheimer disease.