Tumorigenesis5 Genes-uracil-DNA glycosylase(hyper-IgM syndrome [57])-caspase 9, apoptosis-related(colon cancer [42], inflammatory bowel disease [43])-cysteine peptidase-bridging integrator 3-beclin 1(Alzheimer's disease [51], colorectal cancer [56], glioblastoma multiforme [55])-Ras association (RalGDS/AF-6) domain family member 1(cardiac hypertrophy [58,59]). Here, BECN1 is linked to early-onset autosomal dominant Alzheimer disease.