However, there are contradictory reports suggesting a positive correlation between an increase in SM22 levels and colon cancer metastasis to lymph node [31] and increased SM22 levels in gastric cancer [32], though in the latter study it was acknowledged that this was likely due to SM22 associated with the increased vascularisation of the tumour rather than in the tumour cells themselves. This evidence concerns the gene TAGLN and malignant colon neoplasm.