Our laboratory recently has reported that TAT-Pyk2-CT, a fusion protein in which Pyk2 C-terminal domain (amino acid 680-1009) is fused to a cell-permeable TAT peptide, blocks eosinophilic airway inflammation and airway hyperresponsiveness in an ovalbumin- induced mouse model of asthma [17]. The gene discussed is PTK2B; the disease is asthma.