SERPINA7 and liver disorder: The TT3 or TT4 level can be affected by the concentration of thyroxine-binding globulin (TBG) or the binding ability of TBG, which may be affected by some health conditions, such as pregnancy and liver disease, and by a lot of commonly used drugs, including glucocorticoids, nonsteroidal anti-inflammatory drugs, furosemide and heparin.