Low body mass index (P = 0.022), low albumin (P = 0.020), low baseline HCV-RNA level (P = 0.033), genotype 2 (P = 0.033), low baseline platelet count (P < 0.001), and high rate of platelet decline at week 2 (i.e., early platelet decline, P < 0.001) were significantly correlated with the development of severe thrombocytopenia by univariate analysis (Table 2). The gene discussed is ALB; the disease is Thrombocytopenia.