MAPT and early-onset autosomal dominant Alzheimer disease: They include diseases where the tau pathology is the only neuropathological hallmark (such as frontotemporal dementia, Pick's disease, corticobasal degeneration, progressive supranuclear palsy, and others), as well as diseases where the tau pathology coexists with another pathology (such as Alzheimer's disease (AD), Parkinson's disease, and Creutzfeldt-Jakob disease amongst others).