MAPT and tauopathy: Drosophila models of tauopathy have only been used by tau biologists for the last ten years, and in this time, they have contributed to our understanding of the pathogenesis of tauopathies in a number of ways: (a) they have been pivotal in identifying novel players in the disease process as a result of their amenability to unbiased genetic screens; (b) they have highlighted potential mechanisms of tau-mediated cell death and dysfunction and the significance of the various tau abnormalities in that; (c) they have furthered our understanding of tau turnover in normal and disease states.