Gamma-secretase cleaves APP, and other gamma-secretase substrates also play key roles in APP processing (ADAM10) [183], lipid and cholesterol function (LRP1, LDLR, VLDLR), and other processes relevant to Alzheimer's disease, for example, NOTCH signalling [184]. The gene discussed is VLDLR; the disease is early-onset autosomal dominant Alzheimer disease.