The RCT conducted by Milman et al. [94] demonstrating the reduction of cardiovascular events (myocardial infarct, cardiovascular death, and stroke) by 400 IU/d vitamin E in type 2 diabetics with a haptoglobin 2-2 genotype but not other alleles suggests as well the need to consider nutrient/gene interactions in the study design. The gene discussed is HP; the disease is Stroke.