NAMPT and obesity due to melanocortin 4 receptor deficiency: Together with the report that the injurious effect of visfatin, an adipokine involved in the development of various obesity-associated pathologies, is associated with the formation of LRs-redox signaling platforms and local oxidative stress production via LRs clustering [41], we may be able to regard the process as a general pathway for the ROS production and endothelial damage under different pathological situations.