Recently, lysosome-membrane fusion has been detected in bovine coronary arterial endothelial cells and glomerular endothelial cells especially when the cells encountered with apoptotic stimuluses such as FasL, tumor necrosis factor (TNF)-α, endostatin or homocysteine which has been shown to participate in the ROS production and elicit the endothelial dysfunction [7], [20], [21], [22]. Here, COL18A1 is linked to endothelial dysfunction.