Strikingly, our preliminary studies indicate that stable knockdown of ΔNp63 in bladder cancer cells causes strong inhibition of proliferation, effects that are associated with downreguliation of c-Myc mRNA and protein expression (L. Marquis et al, manuscript under revision), Therefore, we currently favor the idea that ΔNp63's significance as a negative prognostic marker is related to its effects on tumor cell proliferation. The gene discussed is MYC; the disease is neoplasm.