As shown in Figure 8A, before day60, Gadd45γ mRNA expression was unchanged; it then increased from day60 (∼3.23-fold) to 360 (∼3.47-fold) and peaked at day180 (∼7.86-fold) post-infection; it was significantly different between E. multilocularis-infected and non-infected mice at days 180 and 360 post-infection (P < 0.05). This evidence concerns the gene GADD45G and infection.