As shown in Figure 3A and 3B, western blotting showed increased Gadd45β expression from day60 (∼1.75-fold) to 360 (∼2.52-fold); it peaked at day180 (∼62.64-fold) post-infection; there was a significant difference between E. multilocularis-infected and non-infected mice at days 60 and 180 (P < 0.05). This evidence concerns the gene GADD45B and infection.