While only 10–15% of women with ovarian cancer have germline BRCA1 or BRCA2 mutations, recent data suggest that sporadic ovarian cancers can harbor acquired genetic and epigenetic defects in BRCA and in other DNA repair genes and proteins, such as PTEN, RAD51, and Fanconi anemia (FA) genes [7], that may contribute to the “BRCAness profile”. This evidence concerns the gene BRCA2 and ovarian cancer.