Our GD2 positive cell preparations were enriched in CD56+ and NB84+ mononuclear NB cells, showed the same genetic aberration as the primary tumor cells, and expressed NB-specific genes, such as TH, GD2 synthase, Phox2b, ELAV4 and DCX, at the same levels as primary tumor cells. The gene discussed is NCAM1; the disease is neoplasm.