Our data show that the α7nAChR-induced release of noradrenaline significantly stimulated NSCLC proliferation associated with the induction of p-ERK and p-CREB while the observed reversal of these effects by propranolol identify these and potentially other signaling proteins as the downstream effectors of β-ARs. The gene discussed is CTBP1; the disease is non-small cell lung carcinoma.