Our findings are in accord with the “paradoxical” (without long-term desensitization) upregulation of α7nACHR as opposed to the desensitization-induced upregulation of α4β2nAChR in response to chronic nicotine reported in the brain [11], [13] and demonstrate strong analogy to modulations of these receptors in the brain associated with nicotine addiction. This evidence concerns the gene CHRNA7 and nicotine dependence.