PolyQ disorders and Huntington disease in particular are especially attractive for modeling in yeast, because, similar to them, yeast prions rely on domains enriched with Q. As in humans, in yeast aggregation and toxicity of htt increase with polyQ length and targeting of mutant htt into the nucleus alters transcription of a subset of genes and decreases cell viability [3]. The gene discussed is HTT; the disease is juvenile Huntington disease.