When the analyses were limited to only patients in the SS/SD/Sβ0 thalassemia group, there was a significant correlation between TAT and lactate dehydrogenase (r = 0.62, p<0.0001), indirect bilirubin (r = 0.296, p = 0.044), and NT-proBNP (r = 0.32, p = 0.026), with borderline correlation with total bilirubin (r = 0.28, p = 0.053) and absolute monocyte count (r = 0.25, p = 0.089). This evidence concerns the gene NPPB and thalassemia.