The activation of K2P channels in response to ischemia has been demonstrated in vitro by Buckler and Honore [11] and the up-regulation of TREK-2 channels in conjunction with extracellular glutamate clearance was demonstrated in cultured rat astrocytes during anoxia/hypoglycemia by Kucheryavykh and co-authors [12]. The gene discussed is KCNK10; the disease is ischemia.