MMP13 and Marinesco-Sjogren syndrome: The inhibitor used in this study, 5-(4-{4-[4-(4-fluorophenyl)-1,3-oxazol-2-yl]phenoxy}phenoxy)-5-(2-methoxyethyl)pyrimidine-2,4,6 (1H,3H, 5H)-trione (Cmpd-1 which is Cmpd-28 in ref. 26), was chosen from a panel of small molecule MMP13-selective inhibitors for its potency and lack of deleterious side effects of a closely related compound in an animal model of MSS [27].