MMP13 and cancer: For example, elevated levels of MMP13 have been associated with decreased overall survival and lymph node metastasis in breast cancer [5], bone metastasis in renal cell carcinoma [6], poor prognosis of non-small cell lung and colorectal cancers [7], [8] and invasive capability in various other human cancers including melanoma, head and neck and vulvar squamous cell carcinoma [9].