Recently, Overall and coworkers identified a number of novel MMP13 cleavage substrates that may be involved, including inactivation of the chemokine CCL2, activation of platelet derived growth factor-C and cleavage of SAA3, osteoprotegrin, Cut A and antithrombin III [18].We speculate that early treatment of Cmpd-1 may have reduced angiogenic seeding in the initial primary tumor mass, but further analysis is required. This evidence concerns the gene PDGFC and neoplasm.