There were several interesting genes in our study that showed strong evidence of up-regulation, such as FOS, PTGS2, HMGB2, MMP9, LY96, TTRAP, ANXA3 and CREB1. Among them, FOS, PTGS2, HMGB2, LY96, TTRAP, ANXA3 and CREB1 have never been reported to be associated with GBS. The gene discussed is HMGB2; the disease is Guillain-Barre syndrome.