LGR4 and neoplasm: Among the numerous genes present in the 20.7 Mb loss on 11p, common to BeWo and JAR, were LGR4 which plays an important role in female reproduction and in early-stage embryonic development [42] and WT1, the well-known suppressor gene which is implicated in nephroblastoma (Wilms tumor) but also in mesenchymal stem cells tumor [43].