These results suggested that rs3741597 or other SNPs, 14648A/G (rs3741596), 14782T/C (rs3825174), 14952T/A (rs11548651), 14988C/T (rs76753792), and 15375A/G (rs74808898), in strong linkage disequilibrium with rs3741597 might influence susceptibility to atopic dermatitis through higher expression of an ORAI1 transcript. This evidence concerns the gene ORAI1 and atopic eczema.