EIF2A and colonic neoplasm: We treated U-2OS human osteosarcoma cells, which do not induce EIF2A phosphorylation in response to paclitaxel, and HCT116 colon cancer cells, in which EIF2A phosphorylation increases upon treatment with this drug (Figure 8A), with increasing concentrations of paclitaxel, either alone or in combination with CCT020312.