To study the down-stream effects of apoptin and Bcr-Abl interaction, we examined the expression and phosphorylation status of Bcr-Ablp210 and other major down-stream Bcr-Abl targets like STAT5, CrkL, c-Myc and Akt in mouse (32Dp210) and human (K562) CML cell lines. Here, AKT1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.