Proactive clinical interference, like orchidopexy, biopsy, or even gonadectomy, is recommended in patients with 46, XY DSD with maldevelopment of the testes (with or without known gene mutation such as WT1) and, in addition, in patients with PAIS, especially when the gonads are in a nonpalpable position [10]. Here, WT1 is linked to disorder of sexual differentiation.