In addition, Cyclooxygenase-2 (COX-2) and its metabolite prostaglandin E2 (PGE2), two pivotal proinflammatory molecules, have been shown to play crucial roles in the establishment and maintenance of HHV8 latency, and in inflammatory, angiogenic and invasive events during HHV8 infection [32]–[34]. The gene discussed is PTGS2; the disease is human herpesvirus 8 infection.